Why the study?
Does ischaemic preconditioning improve post-ischaemic myocardial performance and reduce infarct size in isolated perfused rat hearts subjected to various periods of ischaemia?
Population
Isolated perfused rat hearts subjected to various periods of sustained ischaemia (15, 20, 30, and 45 min)
Comparison
Ischaemic preconditioning vs Non-preconditioned hearts
Design
Preclinical
Authors
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Preconditioning protects against prolonged but not brief ischaemia in rat hearts; leaves open time-dependent effects and clinical translation.
Does ischaemic preconditioning improve post-ischaemic myocardial performance and reduce infarct size in isolated perfused rat hearts subjected to various periods of ischaemia?
Ischaemic preconditioning improves post-ischaemic myocardial function primarily by limiting infarct size in extensive ischaemia, but does not protect against stunning in short ischaemic periods.
Efstathiou et al. (2001) studied this question.
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