Why the study?
Does ischemic preconditioning improve functional and metabolic recovery of stunned myocardium in a porcine model of ischemia-reperfusion?
Population
Farm pigs (n=29)
Comparison
Ischemic preconditioning prior to 15 minutes of… vs 15 minutes of coronary occlusion followed by 120…
Design
Preclinical, randomly assigned
Follow-up
120 minutes of reperfusion
Authors
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Preserves ATP without attenuating stunning in porcine hearts; leaves open translation of metabolic effects to functional recovery.
Does ischemic preconditioning improve functional and metabolic recovery of stunned myocardium in a porcine model of ischemia-reperfusion?
Ischemic preconditioning improves energy metabolism during reperfusion but fails to attenuate myocardial stunning in porcine hearts.
Miyamae et al. (1993) studied this question.
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