Why the study?
Does ischemic preconditioning prevent coronary endothelial dysfunction induced by ischemia and reperfusion in rats?
Population
Rats (n=8 per group in 4 main groups and 2 additional groups)
Comparison
Ischemic preconditioning prior to 20 minutes of… vs Sham surgery, 20 minutes of occlusion without…
Design
Preclinical
Follow-up
1 hour of reperfusion
Authors
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Ischemic preconditioning preserves endothelial function in rat I/R; leaves open translation to clinical cardioprotection.
Does ischemic preconditioning prevent coronary endothelial dysfunction induced by ischemia and reperfusion in rats?
Ischemic preconditioning protects coronary endothelial cells against ischemia/reperfusion injury in addition to protecting myocardial cells.
Richard et al. (1994) studied this question.
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