March 1, 1992Cardiovascular Research
Cardioprotective effects of ischaemic preconditioning are not mediated by prostanoids
Why the study?
Does aspirin prevent the cardioprotective effect of ischemic preconditioning in a rat model of myocardial ischemia-reperfusion?
Population
Female Sprague-Dawley rats weighing between 235-500 g (n=37)
Comparison
Aspirin given 10 min prior to ischemic… vs Control and Preconditioning alone
Design
Preclinical
Follow-up
4.5 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Aspirin does not block preconditioning cardioprotection in rats; leaves open prostanoid-independent mechanisms and clinical translation.
Structured PICO
Does aspirin prevent the cardioprotective effect of ischemic preconditioning in a rat model of myocardial ischemia-reperfusion?
P
Population
Female Sprague-Dawley rats weighing between 235-500 g (n=37)
I
Intervention
Aspirin (10 mg/kg) given 10 min prior to ischemic preconditioning (three repeated episodes of 3 min coronary occlusion and 5 min reperfusion) followed by 90 min occlusion and 4 h reperfusion
C
Comparator
Control (90 min occlusion and 4.5 h reperfusion) and Preconditioning alone (without aspirin)
O
Outcome
Area of necrosis (AN) as a percentage of area at risk (AR)surrogate
Ischemic preconditioning reduces infarct size and ventricular arrhythmias in a rat model, and this cardioprotective effect is not mediated by prostanoids as it is not blocked by aspirin.
Cite This Study
Li et al. (1992) studied this question.