Key result
Ischaemic preconditioning reduced the incidence of ventricular fibrillation during a subsequent 25-minute occlusion from 40% to 0% (p<0.05) and increased survival from 0% to 40%.
Why the study?
Does ischaemic preconditioning reduce ischaemia and reperfusion-induced arrhythmias in a canine model of prolonged coronary occlusion, and is this mediated by cyclo-oxygenase products?
Does ischaemic preconditioning reduce ischaemia and reperfusion-induced arrhythmias in a canine model of prolonged coronary occlusion, and is this mediated by cyclo-oxygenase products?
Ischaemic preconditioning protects against arrhythmias and improves survival during prolonged coronary occlusion in a canine model, an effect that appears to be mediated by the cyclo-oxygenase pathway.
Animal preconditioning reduced ischemia-induced arrhythmias; leaves open clinical relevance and cyclo-oxygenase mediation in humans.
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Végh et al. (1990) studied Myocardial ischaemia and arrhythmias (n=46). Ischaemic preconditioning vs. No preconditioning was evaluated on Ventricular fibrillation during a 25-minute occlusion (p=<0.05). Ischaemic preconditioning reduced the incidence of ventricular fibrillation during a subsequent 25-minute occlusion from 40% to 0% (p<0.05) and increased survival from 0% to 40%.
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