May 1, 1992Cardiovascular Research

Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats

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Why the study?

Does ischemic preconditioning reduce ischemia-induced arrhythmias during prolonged coronary occlusion in anesthetized rats and dogs?

Population

102 anaesthetised rats and 55 anaesthetised dogs

Comparison

Ischemic preconditioning vs Control

Design

Preclinical

Authors

ÁVÁ VéghSemmelweis University SKSadayoshi KomoriUniversity of Szeged LSL SzekeresSemmelweis University

Discussion

Member takes

Implication

Does not support clinical adoption; leaves open translation of preconditioning protection to human arrhythmia trials.

Structured PICO

Does ischemic preconditioning reduce ischemia-induced arrhythmias during prolonged coronary occlusion in anesthetized rats and dogs?

Population

102 anaesthetised rats and 55 anaesthetised dogs

Intervention

Ischemic preconditioning (variable number of short coronary artery occlusions of varying duration and reperfusion periods)

Comparator

Control (no preconditioning prior to prolonged coronary artery occlusion)

Outcome

Severity of ischaemia induced arrhythmias, epicardial ST segment changes, and alterations in the degree of inhomogeneity of conduction during a subsequent prolonged coronary artery occlusionsurrogate

Short periods of myocardial ischemia (preconditioning) protect the myocardium against arrhythmogenic effects of subsequent prolonged occlusion in rats and dogs.

Cite This Study

Végh et al. (1992) studied this question.

synapsesocial.com/papers/6a1ffa29d47ed904550dad90 https://doi.org/10.1093/cvr/26.5.487

View Full Paper

Ask AI

Bookmark

Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider