December 1, 1993Cardiovascular Research
Preconditioning and reperfusion arrhythmias in the isolated rat heart: true protection or temporal shift in vulnerability?
Why the study?
Does ischaemic preconditioning reduce reperfusion-induced ventricular arrhythmias in isolated rat hearts?
Population
Isolated rat hearts Langendorff-perfused with whole blood from a support rat (n = 12 per group)
Comparison
Repeated cycles of ischaemic preconditioning vs Control group (0 cycles of preconditioning)
Design
Preclinical
Authors
Discussion
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Implication
Preconditioning may protect isolated rat hearts from reperfusion VF; leaves open translation to clinical settings.
Structured PICO
Does ischaemic preconditioning reduce reperfusion-induced ventricular arrhythmias in isolated rat hearts?
P
Population
Isolated rat hearts Langendorff-perfused with whole blood from a support rat (n = 12 per group)
I
Intervention
Repeated cycles of ischaemic preconditioning (5 min ischaemia and 5 min reperfusion)
C
Comparator
Control group (0 cycles of preconditioning)
O
Outcome
Incidence of reperfusion induced ventricular fibrillation and ventricular tachycardiasurrogate
Serial preconditioning cycles provide cumulative protection against reperfusion-induced ventricular arrhythmias in isolated rat hearts without altering the temporal relationship between ischaemia duration and arrhythmia severity.
Cite This Study
Lawson et al. (1993) studied this question.