Key result
Slow pacing reduces reperfusion-induced VF by ~67% in isolated hearts.
Why the study?
Heart rate may influence vulnerability to reperfusion induced ventricular arrhythmias, but the protective effect of slow heart rate was not well characterized.
Does slow heart rate pacing reduce reperfusion-induced arrhythmias in isolated ischemic rat hearts?
Population
Isolated perfused rat hearts subjected to transient regional ischaemia
Comparison
Slow heart rate pacing at 200 beats.min-1 vs unpaced controls and faster heart rates
Design
Preclinical experimental study
Follow-up
30 min of reperfusion
Authors
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No immediate clinical implications for reperfusion arrhythmias; leaves open translation of rate effects to in vivo models.
Does slow heart rate pacing reduce reperfusion-induced arrhythmias in isolated ischemic rat hearts?
Slow heart rate pacing delays and reduces the vulnerability of the myocardium to reperfusion-induced ventricular arrhythmias in a rat model.
Tósaki et al. (1988) studied Reperfusion induced arrhythmias (n=24). Slow heart rate (pacing) vs. Unpaced controls was evaluated on Incidence of total ventricular fibrillation and ventricular tachycardia. In isolated rat hearts, pacing at a slow heart rate of 200 beats/min reduced the incidence of reperfusion-induced ventricular fibrillation to 33% and ventricular tachycardia to 50% of control values.
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