Key result
Transient reduction of perfusate calcium to 0.1 mM before ischemia and reperfusion significantly reduced the incidence of ventricular fibrillation from 83% to 17% (P<0.01) in isolated rat hearts.
Why the study?
Does transient calcium reduction prevent reperfusion-induced ventricular fibrillation in isolated rat hearts?
Population
Isolated rat hearts subjected to regional ischemia
Comparison
Transient reduction of perfusate Ca2+ before… vs Control perfusate Ca2+ of 2.4 mM
Design
Preclinical
Authors
Loading...
Should not change clinical practice; leaves open calcium modulation against reperfusion VF in translational models.
Does transient calcium reduction prevent reperfusion-induced ventricular fibrillation in isolated rat hearts?
Absolute Event Rate: 17% vs 83%
p-value: p=<0.01
Transient reduction of extracellular calcium before ischemia and/or during reperfusion significantly reduces the incidence of reperfusion-induced ventricular fibrillation in an isolated rat heart model.
Tósaki et al. (1987) studied Reperfusion-induced arrhythmias. Transient calcium reduction vs. 2.4 mM Ca2+ (control) was evaluated on Incidence of reperfusion-induced ventricular fibrillation (VF) (p=<0.01). Transient reduction of perfusate calcium to 0.1 mM before ischemia and reperfusion significantly reduced the incidence of ventricular fibrillation from 83% to 17% (P<0.01) in isolated rat hearts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: