Population
Isolated perfused intact rat hearts (n=27)
Comparison
Varying perfusate calcium concentrations during… vs Comparison between different perfusate calcium…
Design
Preclinical
Follow-up
10 min ischemia and reperfusion
Authors
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Higher calcium promotes reperfusion arrhythmias in rat hearts; hypothesis-generating for calcium modulation in clinical reperfusion injury.
Abrupt increases in peak intracellular calcium upon reperfusion are strongly associated with the initiation of ventricular arrhythmias in an isolated rat heart model.
Brooks et al. (1995) studied this question.
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