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August 1, 1989Circulation

Cell calcium in the pathophysiology of ventricular fibrillation and in the pathogenesis of postarrhythmic contractile dysfunction.

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Population

Perfused ferret hearts loaded with the Ca2+ indicator 5F-BAPTA

Comparison

Ventricular fibrillation induced by burst pacing vs Control state and comparison between isovolumic…

Design

Preclinical

Follow-up

20 minutes

Authors

YKYukihiro KoretsuneEMEduardo Marbán

Discussion

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Overview

Calcium overload during VF may drive post-shock stunning; animal data leaves open human therapeutic targeting.

Structured PICO

P
Population
Perfused ferret hearts loaded with the Ca2+ indicator 5F-BAPTA
I
Intervention
Ventricular fibrillation induced by burst pacing
C
Comparator
Control state (pre-fibrillation) and comparison between isovolumic hearts vs. hearts with lowered left ventricular volume during fibrillation
O
Outcome
Intracellular free calcium ([Ca2+]i), pH, high-energy phosphates, and developed pressuresurrogate

Intracellular calcium increases as a direct consequence of ventricular fibrillation, potentially causing postarrhythmic contractile dysfunction (stunning).

Cite This Study

Koretsune et al. (1989) studied this question.

synapsesocial.com/papers/6a0fb0968090e499da600ecchttps://doi.org/10.1161/01.cir.80.2.369
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective effect of verapamil on vulnerability to ventricular fibrillation during myocardial ischaemia and reperfusion1980 · 104 citations
  2. 2Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle.1986 · 318 citations
  3. 3Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators.1983 · 192 citations