Calcium oscillations in digitalis-induced ventricular fibrillation: pathogenetic role and metabolic consequences in isolated ferret hearts.
Why the study?
Are intracellular calcium oscillations obligatory in the pathogenesis of ventricular fibrillation during digitalis toxicity, and what are their metabolic consequences?
Population
Isolated ferret hearts Langendorff-perfused at constant flow with oxygenated HEPES-buffered Tyrode's…
Design
Preclinical
Authors
Discussion
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Implication
Ryanodine abolishes pressure but not voltage oscillations in digitalis toxicity; leaves open whether Ca oscillations are obligatory for VF or only drive metabolic decline.
Structured PICO
Are intracellular calcium oscillations obligatory in the pathogenesis of ventricular fibrillation during digitalis toxicity, and what are their metabolic consequences?
P
Population
Isolated ferret hearts (n = 20) Langendorff-perfused at constant flow with oxygenated HEPES-buffered Tyrode's solution at 37 degrees C
I
Intervention
Strophanthidin (20 microM) added during pacing at 3 Hz, followed by exposure to ryanodine
O
Outcome
Role of intracellular free calcium concentration ([Ca2+]i) oscillations in the pathogenesis of ventricular fibrillation and their metabolic consequencessurrogate
Intracellular calcium oscillations are not required to sustain digitalis-induced ventricular fibrillation, but they contribute significantly to metabolic deterioration.
Cite This Study
Kusuoka et al. (1988) studied this question.