What does this research mean for the field?

Spontaneous oscillations of intracellular calcium in ventricular muscle are caused by oscillatory calcium release from the sarcoplasmic reticulum, and stimulated oscillations are likely a synchronization of these spontaneous events. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1984The Journal of PhysiologyOpen Access

Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle.

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Population

Ferret papillary muscles (ventricular muscle) injected with photoprotein aequorin

Design

Preclinical

Authors

DADavid G. AllenUniversity of North Carolina at Chapel Hill DEDavid EisnerElectrophysiology COClive H. OrchardElectrophysiology

Discussion

Member takes

Implication

SR Ca release drives ventricular oscillations in ferret muscle; leaves open relevance to human Ca-dependent arrhythmias.

Structured PICO

Population

Ferret papillary muscles (ventricular muscle) injected with photoprotein aequorin

Intervention

Increasing intracellular Ca concentration via decreased extracellular Na or strophanthidin, and application of caffeine, ryanodine, or D-600

Outcome

Spontaneous and stimulated oscillations of intracellular calcium concentration ([Ca2+]i) and tensionsurrogate

Spontaneous oscillations of intracellular calcium in ferret ventricular muscle are likely due to oscillatory calcium release from the sarcoplasmic reticulum.

Cite This Study

Allen et al. (1984) studied this question.

synapsesocial.com/papers/6a158b1dd64fa333899fcad2 https://doi.org/10.1113/jphysiol.1984.sp015281

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Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider