Key result
Muscle length changes in ferret ventricular muscles altered intracellular Ca2+ transients, indicating that troponin-C affinity is influenced by developed tension and cross-bridge attachment.
Population
Ferret ventricular muscles
Comparison
Muscle length change during twitch contraction… vs Muscle at maximum length or absence of caffeine
Design
Preclinical
Authors
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No immediate clinical implications; leaves open length-dependent Ca2+ mechanisms in human myocardium.
This study demonstrates that the affinity of troponin-C for calcium in ventricular muscle is dynamically influenced by developed tension and cross-bridge attachment/detachment.
Kurihara et al. (1995) studied this question. Muscle length change was evaluated on Intracellular Ca2+ transients. Muscle length changes in ferret ventricular muscles altered intracellular Ca2+ transients, indicating that troponin-C affinity is influenced by developed tension and cross-bridge attachment.
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