What question did this study set out to answer?

This research aims to investigate how changes in muscle length during the diastolic phase influence calcium transients and developed tension in ventricular muscle.

December 1, 1988The Journal of PhysiologyOpen Access

The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle.

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Population

Ferret papillary muscles isolated and injected with aequorin

Comparison

Changes in muscle length vs Long length / baseline length

Design

Preclinical

Authors

DADavid G. AllenUniversity of North Carolina at Chapel Hill CNColin G. NicholsElectrophysiology GSGodfrey L. SmithElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating for length-dependent Ca2+ handling in ventricular muscle; leaves open translation to human cardiac physiology.

Key Points

This research aims to investigate how changes in muscle length during the diastolic phase influence calcium transients and developed tension in ventricular muscle.
Isolated ferret papillary muscles were injected with aequorin to measure intracellular calcium concentration.
Muscle length changes were induced, and the developed tension along with calcium transients was recorded during different contraction phases.
Recovery of tension and calcium transients was assessed after resting at varying muscle lengths.
A maintained reduction in muscle length resulted in an immediate decrease in developed tension (exact metrics not provided) followed by a slower decline over 10-20 min.
The amplitude of the systolic calcium transient decreased, while the twitch duration was abbreviated when muscle length was reduced.
Resting at a shorter muscle length resulted in diminished recovery of both developed tension and calcium transients compared to resting at a longer length.

Structured PICO

Population

Ferret papillary muscles isolated and injected with aequorin

Intervention

Changes in muscle length (maintained reduction, systolic shortening, diastolic shortening)

Comparator

Long length / baseline length

Outcome

Intracellular Ca2+ concentration ([Ca2+]i) and developed tensionsurrogate

Diastolic muscle length influences resting intracellular calcium concentration, which subsequently affects systolic calcium transients and developed tension in ferret ventricular muscle.

Cite This Study

Allen et al. (1988) studied this question.

synapsesocial.com/papers/6a70abdefe4101aa97e04426 https://doi.org/10.1113/jphysiol.1988.sp017385

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The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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