Key result
In rat cardiac trabeculae, tension increased linearly with sarcomere length at 0.5 mM extracellular calcium, whereas it approached maximal tension exponentially at 2.5 mM calcium.
The study provides evidence for length-dependent activation in cardiac muscle, showing that the relationship between tension and sarcomere length is modulated by extracellular calcium concentration.
No immediate clinical implications; hypothesis-generating for calcium modulation of length-dependent activation in cardiac muscle.
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Keurs et al. (1980) studied Rat cardiac trabeculae. Extracellular calcium concentrations ([Ca2+]o) was evaluated on Relation between tension and sarcomere length. In rat cardiac trabeculae, tension increased linearly with sarcomere length at 0.5 mM extracellular calcium, whereas it approached maximal tension exponentially at 2.5 mM calcium.
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