Population
Right ventricular papillary muscles and trabeculae isolated from hearts of female Wistar rats weighing…
Comparison
Stretching to diastolic lengths of 90, 95, and… vs Comparison across different diastolic muscle…
Design
Preclinical
Key result
Reducing diastolic muscle length from Lmax to 90% Lmax decreased peak developed force and shortened relaxation timing, while increasing the calcium loading capacity of the sarcoplasmic reticulum.
Authors
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May accelerate relaxation via SR calcium in isolated muscle; hypothesis-generating for diastolic length effects, needs human validation.
In rat ventricular muscle, diastolic muscle length differentially influences sarcoplasmic reticular calcium storage and release processes, with greater loading capacity at shorter lengths.
Gamble et al. (1992) studied this question. Diastolic muscle length reduction vs. Lmax (100%) was evaluated on Peak developed force, maximum rate of force development, intrinsic timing, and sarcoplasmic reticular calcium content. Reducing diastolic muscle length from Lmax to 90% Lmax decreased peak developed force and shortened relaxation timing, while increasing the calcium loading capacity of the sarcoplasmic reticulum.