Key result
Peak twitch force was tightly correlated with prolongation of contraction in rat trabeculae, with duration tripling from 100 to 300 ms as force rose from 10 to 100 mN/mm2.
In excised rat trabeculae, peak twitch force, rather than sarcomere length, is the primary determinant of the prolongation of late systolic contraction.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications from rodent trabeculae; leaves open force versus length as primary driver of contraction duration in humans.
Janssen et al. (1995) studied Myocardial contraction (n=9). Varying sarcomere length and extracellular Ca2+ concentration was evaluated on Prolongation of contraction. Peak twitch force was tightly correlated with prolongation of contraction in rat trabeculae, with duration tripling from 100 to 300 ms as force rose from 10 to 100 mN/mm2.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: