Key result
Computational simulations demonstrated that time to 50% relaxation increased by 0.11s over sarcomere lengths from 1.9 μm to 2.2 μm, suggesting high tension in sarcomeres hinders myocardial relaxation.
Computational modeling suggests that prolongation of myocardial contraction at higher tension results from tighter binding of Ca2+ to troponin in areas under higher tension, delaying relaxation.
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Tension-dependent Ca-troponin binding may prolong relaxation under high load; leaves open in vivo validation before mechanistic adoption.
Dupuis et al. (2018) studied Myocardial relaxation. Computational model of sarcomere mechanics was evaluated on Time to 50% relaxation (tR50). Computational simulations demonstrated that time to 50% relaxation increased by 0.11s over sarcomere lengths from 1.9 μm to 2.2 μm, suggesting high tension in sarcomeres hinders myocardial relaxation.
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