Key result
Mechanical alternans in isolated ferret ventricular muscle is associated with in-phase alternation of intracellular calcium and is abolished by caffeine or ryanodine.
Population
Isolated ferret papillary muscles
Comparison
Induction of mechanical alternans via rapid… vs Control conditions
Design
Preclinical
Authors
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Hypothesis-generating for SR calcium in mechanical alternans; does not support practice changes pending in vivo confirmation.
Mechanical alternans is caused by intracellular calcium cycling involving the sarcoplasmic reticulum, and does not require incomplete muscle relaxation between beats.
Lab et al. (1990) studied Mechanical alternans. Caffeine or ryanodine vs. Control conditions was evaluated on Intracellular free calcium concentration and tension. Mechanical alternans in isolated ferret ventricular muscle is associated with in-phase alternation of intracellular calcium and is abolished by caffeine or ryanodine.
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