Population
Mathematical model of a cardiac cell with 75 coupled elements, each containing L-type Ca current, a subspace…
Design
Preclinical
Authors
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Preclinical findings only; leaves open whether SR Ca(2+) alternation sustains alternans independently of channel refractoriness in patients.
Computer modeling demonstrates that intracellular calcium alternans can be generated by propagating waves of calcium release and sustained through alternation of sarcoplasmic reticulum calcium content, independent of channel refractoriness.
O’Neill et al. (2008) studied this question.
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