Key result
In cat atrial myocytes, Ca(2+) alternans is caused by subcellular alterations of SR Ca(2+) release mediated by local inhibition of energy metabolism, generating arrhythmogenic Ca(2+) waves.
Population
Cat atrial myocytes
Comparison
Increasing stimulation frequency or inhibition… vs Normal excitation-contraction coupling
Design
Preclinical
Authors
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Cellular Ca alternans data in atrial myocytes are hypothesis-generating; leaves open clinical translation to arrhythmia prevention.
Subcellular heterogeneities in calcium alternans, driven by local metabolic inhibition, can generate arrhythmogenic calcium waves, providing a novel mechanism for cardiac dysrhythmias.
Blatter et al. (2003) studied Cardiac dysrhythmias (experimental model). Increased stimulation frequency or inhibition of glycolysis vs. Normal excitation-contraction coupling was evaluated on Subcellular Ca(2+) signalling and spatiotemporal [Ca(2+)](i) patterns. In cat atrial myocytes, Ca(2+) alternans is caused by subcellular alterations of SR Ca(2+) release mediated by local inhibition of energy metabolism, generating arrhythmogenic Ca(2+) waves.
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