Key result
Mathematical modeling of ventricular myocytes demonstrated that ion channel stochasticity at the single calcium release unit level can cause phase reversals and influence whole-cell alternans dynamics.
This mathematical modeling study demonstrates that ion channel stochasticity and calcium-voltage coupling significantly influence whole-cell alternans dynamics, providing insights into mechanisms underlying life-threatening ventricular arrhythmias.
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Does not support changes in arrhythmia management; hypothesis-generating for ion channel stochasticity in ventricular alternans.
Restrepo et al. (2009) studied Cardiac alternans. Mathematical modeling of ventricular myocytes was evaluated on Intracellular calcium dynamics during alternans. Mathematical modeling of ventricular myocytes demonstrated that ion channel stochasticity at the single calcium release unit level can cause phase reversals and influence whole-cell alternans dynamics.
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