December 1, 1991AJP Heart and Circulatory Physiology

Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles

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Population

8 papillary muscles isolated from the right ventricles of male ferrets

Design

Preclinical

Authors

YKYasuki KiharaGeneral Cardiology JMJames P. MorganGeneral Cardiology

Discussion

Member takes

Implication

Should not yet guide therapy for mechanical alternans; leaves open sarcoplasmic reticulum calcium handling as a target in humans.

Structured PICO

Population

8 papillary muscles isolated from the right ventricles of male ferrets

Intervention

Perfusion with physiological salt solution containing low calcium (0.25 mM) at 22 degrees C, stimulated at 0.5-1.0 Hz in the presence of carbachol and propranolol, chemically loaded with aequorin

Outcome

Simultaneous recording of aequorin signal (intracellular calcium) and isometric contraction to assess the relationship between peak calcium and peak tensionsurrogate

Mechanical alternans in the heart is primarily caused by alternations in intracellular calcium levels available for myofilament activation, likely due to depressed sarcoplasmic reticulum calcium pump function.

Cite This Study

Kihara et al. (1991) studied this question.

synapsesocial.com/papers/6a1f718d2865985bbe2ad75c https://doi.org/10.1152/ajpheart.1991.261.6.h1746

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Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider