December 1, 1985The Journal of General PhysiologyOpen Access

Effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibers.

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Population

Voltage-clamped sheep cardiac Purkinje fibers

Comparison

Caffeine, tetracaine, and ryanodine vs Varying extracellular calcium concentrations

Design

Preclinical

Authors

CNC.J. NiemanNovartis (Switzerland)DEDavid EisnerElectrophysiology

Discussion

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Implication

Does not support clinical translation; leaves open mechanisms of action beyond intracellular calcium modulation in cardiac tissue.

Structured PICO

Population

Voltage-clamped sheep cardiac Purkinje fibers

Intervention

Caffeine (1-20 mM), tetracaine (100-1000 microM), and ryanodine (0.1-10 microM)

Comparator

Varying extracellular calcium concentrations ([Ca2+]o)

Outcome

Oscillations of membrane current and tension (amplitude and frequency)surrogate

The differential effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep Purkinje fibers suggest these drugs act via mechanisms beyond simply altering intracellular calcium.

Cite This Study

Nieman et al. (1985) studied this question.

synapsesocial.com/papers/6a83d2478df3fed3c85bd772 https://doi.org/10.1085/jgp.86.6.877

View Full Paper

Ask AI

Bookmark

Effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of caffeine, tetracaine, and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibers.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider