Key result
Reperfusion after global ischaemia produced a transient increase in cytosolic Ca2+ that was temporally associated with a mirror-like decrease in sarcoplasmic reticulum Ca2+ content.
Population
Langendorff-perfused mouse hearts loaded with fluorescent dyes Rhod-2, Mag-fluo-4, and Di-8-ANEPPS
Design
Preclinical
Authors
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May explain early reperfusion arrhythmias; hypothesis-generating in animal hearts and leaves open clinical translation.
This study provides the first evidence in intact hearts that the sarcoplasmic reticulum contributes to cytosolic Ca2+ overload during reperfusion, which may explain early reperfusion arrhythmias.
Valverde et al. (2009) studied Myocardial stunning / Ischaemia-reperfusion injury. Global ischaemia and reperfusion vs. Baseline was evaluated on Cytosolic Ca2+, sarcoplasmic reticulum (SR) Ca2+, and transmembrane action potentials. Reperfusion after global ischaemia produced a transient increase in cytosolic Ca2+ that was temporally associated with a mirror-like decrease in sarcoplasmic reticulum Ca2+ content.
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