August 1, 1989Circulation ResearchOpen Access

Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium.

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Population

5 open-chest dogs

Comparison

Regional myocardial stunning produced by eight… vs Sarcoplasmic reticulum from normal myocardium

Design

Preclinical

Follow-up

60-minute period of reperfusion

Authors

SKStephen M. KrauseFriedrich Baur Stiftung WJWilliam E. JacobusBrigham and Women's Hospital LBLewis C. BeckerCardiac Imaging

Discussion

Member takes

Implication

May explain postischemic dysfunction in this model; leaves open relevance to human stunning or therapy.

Structured PICO

Population

5 open-chest dogs

Intervention

Regional myocardial stunning produced by eight to twelve 5-minute occlusions of the left anterior descending coronary artery, alternated with 10-minute reflow periods and followed by a final 60-minute period of reperfusion

Comparator

Sarcoplasmic reticulum from normal myocardium

Outcome

Oxalate-supported 45Ca2+ transport in isolated sarcoplasmic reticulumsurrogate

Myocardial stunning is associated with damage to the calcium-transport system of the sarcoplasmic reticulum, which may contribute to postischemic mechanical depression.

Cite This Study

Krause et al. (1989) studied this question.

synapsesocial.com/papers/6a7e18e7bcaf28b5c937ed58 https://doi.org/10.1161/01.res.65.2.526

View Full Paper

Ask AI

Bookmark

Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider