Population
In vivo open-chest porcine heart model (n=5)
Comparison
45 minutes of low-flow left anterior descending… vs Preischemic myocardium in the LAD perfusion bed…
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Reduced myofilament Ca2+ sensitivity contributes to stunning in this model; leaves open translation to human postischemic dysfunction.
Postischemic myocardial stunning is associated with decreased myofilament calcium sensitivity rather than a decrease in maximal tension-generating capability.
Hofmann et al. (1993) studied this question.
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