What does this research mean for the field?

Myocardial stunning is a reversible contractile dysfunction primarily driven by a loss of calcium responsiveness in the cardiac myofilaments. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To review the pathophysiological mechanisms of myocardial stunning after brief ischemia and evaluate myofilament calcium responsiveness as a key target for cardioprotective preconditioning.

June 1, 1999Cardiovascular ResearchOpen Access

Preconditioning and limitation of stunning one step closer to the protected protein(s)?

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Design

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Authors

JLJos M. J. LamersDiakonessenhuis hospital

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Implication

Discusses the mechanisms underlying myocardial stunning, specifically the loss of calcium responsiveness of myofilaments.

Key Points

To review the pathophysiological mechanisms of myocardial stunning after brief ischemia and evaluate myofilament calcium responsiveness as a key target for cardioprotective preconditioning.
Synthesis of findings from historical in vivo canine models measuring regional contractility recovery after 5-minute and 15-minute left anterior descending coronary artery occlusions.
Analysis of isolated perfused ferret hearts and in situ porcine models evaluating myofibril mechanics and sarcoplasmic reticulum calcium handling.
Examination of myocardial contractility and p[Ca2+]/Mg2+-ATPase curves following administration of the calcium sensitizer EMD 60263 in stunned porcine myocardium.
Brief coronary artery occlusions induced fully reversible contractile dysfunction requiring several hours (after 5 minutes of occlusion) up to 24 hours (after 15 minutes of occlusion) for complete recovery.
Loss of myofilament calcium responsiveness, rather than sarcoplasmic reticulum calcium pump failure, was confirmed as the primary driver of reversible contractile impairment.
Calcium sensitizer EMD 60263 selectively increased segment length shortening to a greater extent in stunned than in non-stunned porcine myocardium, shifting myofibrillar calcium-ATPase curves upward and to the left.

Cite This Study

Jos M. J. Lamers (1999) studied this question.

synapsesocial.com/papers/6a1c6eec973ffece4bc3cf8f https://doi.org/10.1016/s0008-6363(99)00086-3

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Preconditioning and limitation of stunning one step closer to the protected protein(s)?

Discussion

Member takes

Implication

Key Points

Cite This Study

Preconditioning and limitation of stunning one step closer to the protected protein(s)?

Discussion

Member takes

Implication

Key Points

Cite This Study

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