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Does low-flow ischemia and reperfusion alter myofilament Ca2+ sensitivity and maximum velocity of shortening in a porcine model of myocardial stunning?
Does low-flow ischemia and reperfusion alter myofilament Ca2+ sensitivity and maximum velocity of shortening in a porcine model of myocardial stunning?
In a porcine model of myocardial stunning, depressed contractile function is associated with reduced maximum velocity of shortening rather than changes in myofilament Ca2+ sensitivity, except in severe ischemia.
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Implicates reduced shortening velocity in stunning mechanisms; leaves open Ca2+ sensitivity role pending human validation.
McDonald et al. (1995) studied this question.
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