Population
Isolated myocytes from chronically instrumented pigs and rats
Comparison
90-minute coronary stenosis followed by… vs Nonischemic (normal) region myocytes
Design
Preclinical
Authors
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Challenges troponin-centric stunning paradigm from rodents; leaves open calcium-handling mechanisms in large mammals pending human data.
Myocardial stunning in a large animal (pig) model is driven by impaired calcium handling and phospholamban dephosphorylation, challenging the prevailing rodent-derived paradigm of troponin I degradation.
Kim et al. (2001) studied this question.
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