Key result
High heart rate pacing (≥420 beats/min) during ischemia increased reperfusion-induced ventricular fibrillation to >90%, compared to 25% in unpaced isolated rat hearts.
Population
573 isolated rat hearts
Comparison
Pacing at various rates during ischemia and/or… vs Unpaced hearts or hearts paced at lower rates
Design
Preclinical
Follow-up
Up to 40 min of coronary occlusion and 10 min reperfusion
Authors
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Tachycardia during ischemia heightens reperfusion VF risk in rat hearts; extends experimental data but leaves clinical translation open.
Absolute Event Rate: 90% vs 25%
Higher heart rates during ischemia exacerbate the development of ischemic injury and increase susceptibility to subsequent reperfusion-induced ventricular fibrillation.
Bernier et al. (1989) studied Ischemia-induced and reperfusion-induced arrhythmias (n=573). High heart rate pacing vs. Unpaced hearts was evaluated on Incidence of reperfusion-induced ventricular fibrillation (VF). High heart rate pacing (≥420 beats/min) during ischemia increased reperfusion-induced ventricular fibrillation to >90%, compared to 25% in unpaced isolated rat hearts.
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