Key result
Antiarrhythmic agents blocking the fast inward sodium current significantly reduced reperfusion-induced ventricular fibrillation in a rat model with a 50-56% baseline incidence.
Population
Pentobarbitone-anaesthetized rat model with occlusion of the left main coronary artery and subsequent release
Design
Preclinical
Follow-up
1-2 minutes post-release
Authors
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Hypothesis-generating for sodium channel blockade in reperfusion VF; leaves open translation to human arrhythmias.
In a rat model, reperfusion-induced arrhythmias are particularly susceptible to drugs that block the fast inward sodium current, but not to beta-blockers or calcium antagonists.
Kane et al. (1984) studied Reperfusion-induced arrhythmias. Antiarrhythmic agents (Org 6001, melperone, bepridil, atenolol, calcium antagonists) was evaluated on Incidence of reperfusion-induced ventricular fibrillation. Antiarrhythmic agents blocking the fast inward sodium current significantly reduced reperfusion-induced ventricular fibrillation in a rat model with a 50-56% baseline incidence.
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