Key result
Antidepressants such as imipramine, metapramine, mianserin, and nomifensine prevented reperfusion arrhythmias in a concentration-dependent manner in isolated rat hearts, whereas amineptine did not.
Why the study?
Do antidepressant drugs prevent reperfusion arrhythmias in isolated rat hearts subjected to myocardial ischaemia and reperfusion?
Do antidepressant drugs prevent reperfusion arrhythmias in isolated rat hearts subjected to myocardial ischaemia and reperfusion?
Certain antidepressants prevent reperfusion arrhythmias in isolated rat hearts, likely through a quinidine-like mechanism.
Answers are grounded in this paper and cite their sources.
Does not support clinical use; hypothesis-generating for select antidepressants in reperfusion arrhythmias.
Rat isolated hearts were perfused according to the Langendorff's method. The hearts were prelabelled with 3H-noradrenaline (3H-NA) and the left coronary artery was occluded during 10 min. The liberation of 3H-NA and the development of ventricular arrhythmias were investigated during ischaemia and the following reperfusion period. In control preparations, reperfusion was followed by ventricular fibrillation and a sudden release of radioactivity in the coronary effluent. Antidepressants such as imipramine, metapramine, mianserin and nomifensine prevented reperfusion arrhythmias in a concentration-dependent manner and caused bradycardia. Amineptine, however, was ineffective in preventing reperfusion arrhythmias even in a high concentration, this agent did not decrease heart rate. Nevertheless none of the antidepressants changed the rate of liberation of 3H-NA during the ligation and reperfusion periods. A quinidine like action seems the most appropriate explanation for the cardiac effects of these antidepressant drugs.
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Bril et al. (1987) studied Myocardial ischaemia and reperfusion arrhythmias. Antidepressant drugs (imipramine, metapramine, mianserin, nomifensine, amineptine) vs. Control preparations was evaluated on Development of ventricular arrhythmias and liberation of 3H-NA. Antidepressants such as imipramine, metapramine, mianserin, and nomifensine prevented reperfusion arrhythmias in a concentration-dependent manner in isolated rat hearts, whereas amineptine did not.
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