The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts.
Why the study?
Does adenosine receptor activation mediate the cardioprotective effect of ischemic preconditioning in a rat model?
Population
Rat model undergoing 90 minutes of coronary artery occlusion followed by 4 hours of reperfusion
Comparison
8-theophylline or adenosine, with or without… vs Control (nonpreconditioned) + vehicle
Design
Preclinical
Follow-up
4 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Adenosine does not mediate preconditioning cardioprotection in rats; leaves open species-specific mechanisms and cautions against clinical extrapolation.
Structured PICO
Does adenosine receptor activation mediate the cardioprotective effect of ischemic preconditioning in a rat model?
P
Population
Rat model undergoing 90 minutes of coronary artery occlusion followed by 4 hours of reperfusion
I
Intervention
8-(p-sulfophenyl)theophylline (SPT) or adenosine, with or without ischemic preconditioning (three 3-minute episodes of ischemia separated by 5 minutes of reperfusion)
C
Comparator
Control (nonpreconditioned) + vehicle
O
Outcome
Myocardial infarct size expressed as a percentage of the area at risksurrogate
Adenosine receptor activation does not mediate the cardioprotective effects of ischemic preconditioning in rat hearts, contrasting with findings in other species.
Cite This Study
Li et al. (1993) studied this question.