Why the study?
Does adenosine receptor activation play a role in myocardial infarct size limitation by ischaemic preconditioning in a rabbit model?
Population
Male rabbits in a chronic model of myocardial infarction induced by 30 min left coronary artery occlusion…
Comparison
Preconditioning, 8-phenyltheophylline, R-PIA, or… vs Untreated control
Design
Preclinical
Follow-up
72 h reperfusion
Authors
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Hypothesis-generating for adenosine-mediated cardioprotection; human translation untested and should not alter practice.
Does adenosine receptor activation play a role in myocardial infarct size limitation by ischaemic preconditioning in a rabbit model?
Adenosine receptor activation plays a crucial role in the mechanism of ischaemic preconditioning to limit myocardial infarct size in a rabbit model.
Tsuchida et al. (1992) studied this question.
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