Why the study?
Does dipyridamole potentiate the infarct size-limiting effect of ischemic preconditioning in a rabbit model of myocardial ischemia-reperfusion?
Population
Rabbits undergoing 30-minute coronary occlusion and 72-hour reperfusion (n=61)
Comparison
Dipyridamole administered before 2-minute… vs Control, preconditioning alone, and other…
Design
Preclinical
Follow-up
72 hours
Authors
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May support adenosine's role in preconditioning; leaves open clinical translation in humans.
Does dipyridamole potentiate the infarct size-limiting effect of ischemic preconditioning in a rabbit model of myocardial ischemia-reperfusion?
Dipyridamole significantly potentiates the infarct size-limiting effect of ischemic preconditioning in a rabbit model, supporting the role of endogenous adenosine in ischemic tolerance.
Miura et al. (1992) studied this question.
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