January 1, 1998Journal of Cardiovascular Pharmacology

Infarct-Size Limitation by Preconditioning is Enhanced by Dipyridamole Administered Before But Not After Preconditioning: Evidence for the Role of Interstitial Adenosine Level During Preconditioning as a Primary Determinant of Cardioprotection

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Why the study?

Does dipyridamole administered before ischemic preconditioning reduce infarct size in a rabbit model of myocardial infarction?

Population

Rabbit model of myocardial infarction induced by 30-min coronary artery occlusion and 3-h reperfusion

Comparison

Dipyridamole administered before or after… vs No treatment, dipyridamole alone…

Design

Preclinical

Follow-up

3-h reperfusion

Authors

KSKatsuo SuzukiKeio University TMTetsuji MiuraHeart Failure / Cardiomyopathy TMTakayuki MikiTokyo Medical and Dental University

Discussion

Member takes

Implication

Supports adenosine augmentation of preconditioning in rabbits; leaves open translation to human myocardial infarction.

Structured PICO

Does dipyridamole administered before ischemic preconditioning reduce infarct size in a rabbit model of myocardial infarction?

Population

Rabbit model of myocardial infarction induced by 30-min coronary artery occlusion and 3-h reperfusion

Intervention

Dipyridamole (0.25 mg/kg, i.v.) administered before or after ischemic preconditioning (2-min or 3-min ischemia)

Comparator

No treatment, dipyridamole alone, preconditioning alone, or 8-sulfophenyltheophylline (SPT) after preconditioning

Outcome

Infarct size determined by tetrazolium staining and expressed as percentage of area at risk (%IS/AR)surrogate

Enhancing interstitial adenosine levels with dipyridamole before ischemic preconditioning significantly reduces infarct size, indicating that adenosine levels during preconditioning are a primary determinant of cardioprotection.

Cite This Study

Suzuki et al. (1998) studied this question.

synapsesocial.com/papers/6a90e43ee6edfa081370f487 https://doi.org/10.1097/00005344-199801000-00001

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Infarct-Size Limitation by Preconditioning is Enhanced by Dipyridamole Administered Before But Not After Preconditioning: Evidence for the Role of Interstitial Adenosine Level During Preconditioning as a Primary Determinant of Cardioprotection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Infarct-Size Limitation by Preconditioning is Enhanced by Dipyridamole Administered Before But Not After Preconditioning: Evidence for the Role of Interstitial Adenosine Level During Preconditioning as a Primary Determinant of Cardioprotection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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