Why the study?
Does pretreatment with CCPA reduce infarct size in a rabbit model of myocardial infarction?
Population
Rabbit model of myocardial infarction induced by a 30 min coronary occlusion
Comparison
Pretreatment with 0.125 mg.kg-1 CCPA, or 0.25… vs Control group receiving no treatment
Design
Preclinical
Follow-up
72 hours
Authors
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CCPA pretreatment merits further cardioprotection study in animals; leaves open translation to human MI therapy.
Does pretreatment with CCPA reduce infarct size in a rabbit model of myocardial infarction?
Pretreatment with the adenosine A1 receptor agonist CCPA significantly reduces infarct size in a rabbit model of myocardial infarction, an effect that persists at 72 hours.
Tsuchida et al. (1993) studied this question.
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