May 1, 1997Journal of Cardiovascular Pharmacology
Time Course of Delayed Myocardial Protection After Transient Adenosine A1-Receptor Activation in the Rabbit
Why the study?
Does transient adenosine A1-receptor activation with CCPA reduce infarct size in a rabbit model of myocardial ischemia-reperfusion?
Population
Rabbits subjected to 30 min reversible occlusion of a left branch of the circumflex coronary artery followed…
Comparison
Single dose of 2-chloro-N6-cyclopentyladenosine… vs Time-matched saline i.v. pretreatment
Design
Preclinical
Follow-up
24, 48, 72, or 96 h after treatment
Authors
Discussion
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Implication
Hypothesis-generating for delayed A1-mediated cardioprotection in rabbits; leaves open translation to human myocardial infarction.
Structured PICO
Does transient adenosine A1-receptor activation with CCPA reduce infarct size in a rabbit model of myocardial ischemia-reperfusion?
P
Population
Rabbits subjected to 30 min reversible occlusion of a left branch of the circumflex coronary artery followed by 120 min reperfusion
I
Intervention
Single dose of 2-chloro-N6-cyclopentyladenosine (CCPA) 100 micrograms/kg i.v. administered 24, 48, 72, or 96 h prior to ischemia
C
Comparator
Time-matched saline i.v. pretreatment
O
Outcome
Infarct size determined as a percentage of the myocardial risk volume by triphenyltetrazolium stainingsurrogate
Transient adenosine A1-receptor activation provides delayed myocardial protection against infarction for up to 72 hours in rabbits, independent of hsp70i induction.
Cite This Study
Baxter et al. (1997) studied this question.