A1or A3Adenosine Receptors Induce Late Preconditioning Against Infarction in Conscious Rabbits by Different Mechanisms
Why the study?
Does pretreatment with A1 or A3 adenosine receptor agonists reduce infarct size in conscious rabbits?
Population
Conscious rabbits
Comparison
Pretreatment 24 hours earlier with selective… vs Vehicle-treated rabbits
Design
Preclinical
Follow-up
72 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Should not yet change clinical practice; hypothesis-generating for A1/A3 agonism in late preconditioning.
Structured PICO
Does pretreatment with A1 or A3 adenosine receptor agonists reduce infarct size in conscious rabbits?
P
Population
Conscious rabbits
I
Intervention
Pretreatment 24 hours earlier with selective adenosine receptor agonists CCPA (100 microgram/kg IV bolus) or IB-MECA (100 or 300 microgram/kg)
C
Comparator
Vehicle-treated rabbits
O
Outcome
Size of the infarct induced by 30 minutes of coronary artery occlusion and 72 hours of reperfusionsurrogate
Activation of A1 or A3 adenosine receptors induces late preconditioning against infarction in conscious rabbits via K(ATP) channels, with A1AR using an NOS-dependent pathway and A3AR using an NOS-independent pathway.
Cite This Study
Takano et al. (2001) studied this question.