Key result
Perfusion with adenosine reduced the incidence of sustained VT or VF from 92% to 9% in isolated rat hearts, suggesting A1 receptor stimulation triggers protection against ischemia-induced arrhythmias.
Population
Langendorff-perfused rat hearts
Comparison
Preconditioning, perfusion with adenosine, or… vs Control
Design
Preclinical
Authors
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A1-mediated antiarrhythmic protection in rat hearts is hypothesis-generating; leaves open translation to human ischemia-related arrhythmia prevention.
Absolute Event Rate: 9% vs 92%
Stimulation of the A1 receptor by adenosine mediates ischemic preconditioning-induced protection against ischemia-induced arrhythmias in isolated rat hearts.
Miyatake et al. (1996) studied Ischemia-induced arrhythmias. Adenosine or CCPA vs. Control was evaluated on Incidence of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). Perfusion with adenosine reduced the incidence of sustained VT or VF from 92% to 9% in isolated rat hearts, suggesting A1 receptor stimulation triggers protection against ischemia-induced arrhythmias.
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