Why the study?
Does acadesine lower the temporal threshold for the myocardial infarct size limiting effect of preconditioning in rabbit hearts?
Population
Rabbit hearts subjected to 30 min left coronary artery occlusion and 3 h reperfusion
Comparison
Pretreatment with acadesine prior to 2 min… vs Untreated controls, acadesine alone, or 2 min…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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No clinical implications yet; leaves open translation of acadesine-enhanced preconditioning to humans.
Does acadesine lower the temporal threshold for the myocardial infarct size limiting effect of preconditioning in rabbit hearts?
Acadesine lowers the temporal threshold for ischemic preconditioning to below 2 minutes in a rabbit model, supporting the role of endogenous adenosine in cardioprotection.
Tsuchida et al. (1993) studied this question.
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