Why the study?
Does acadesine extend the window of protection afforded by ischaemic preconditioning in a rabbit heart model of ischaemia-reperfusion?
Population
Rabbit heart model of myocardial infarction
Comparison
Acadesine plus ischaemic preconditioning vs No treatment, preconditioning alone, acadesine…
Design
Preclinical
Follow-up
180 min reperfusion
Authors
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Hypothesis-generating in rabbit ischaemia-reperfusion; leaves open whether adenosine-mediated preconditioning extension applies clinically.
Does acadesine extend the window of protection afforded by ischaemic preconditioning in a rabbit heart model of ischaemia-reperfusion?
Acadesine extends the protective window of ischaemic preconditioning against myocardial infarction in a rabbit model, an effect mediated by adenosine.
Tsuchida et al. (1994) studied this question.
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