January 1, 1999Canadian Journal of Physiology and Pharmacology

Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig

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Why the study?

Does acadesine or adenosine improve interstitial adenosine levels and myocardial stunning in a pig model of ischemia-reperfusion?

Population

Pentobarbital-anesthetized pigs with myocardial stunning induced by 10 min left anterior descending coronary…

Comparison

Acadesine, adenosine, or adenosine plus acadesine vs Control hearts

Design

Preclinical

Follow-up

90 minutes of reperfusion

Authors

RLRobert D. LasleyWayne State University MRMohinder P.S. RandhawaUniversity of Wisconsin–Madison JHJulia HeggeArrowhead Pharmaceuticals (United States)

Discussion

Member takes

Implication

Acadesine fails to augment adenosine or attenuate stunning in a pig model; challenges its proposed mechanism and leaves open clinical translation.

Structured PICO

Does acadesine or adenosine improve interstitial adenosine levels and myocardial stunning in a pig model of ischemia-reperfusion?

Population

Pentobarbital-anesthetized pigs with myocardial stunning induced by 10 min left anterior descending coronary artery occlusion and 90 min reperfusion

Intervention

Acadesine (20 mg/kg i.v. bolus 10 min prior to ischemia + 0.5 mg/kg/min i.v. infusion through 60 min reperfusion), adenosine (100 microg/kg/min intracoronary immediately prior to ischemia), or adenosine plus acadesine

Comparator

Control hearts

Outcome

Interstitial fluid adenosine levels (estimated by cardiac microdialysis) and regional ventricular function (systolic wall thickening)surrogate

Acadesine fails to enhance myocardial adenosine levels or attenuate myocardial stunning in a pig model, contrasting with its proposed cardioprotective mechanism.

Cite This Study

Lasley et al. (1999) studied this question.

synapsesocial.com/papers/6a89b03d158e870006bd4d3f https://doi.org/10.1139/cjpp-77-4-259

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Implication

Acadesine fails to augment adenosine or attenuate stunning in a pig model; challenges its proposed mechanism and leaves open clinical translation.

Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider