Key result
Exogenous intracoronary adenosine augmented postischemic recovery of function in dogs, significantly enhancing systolic wall thickness (7.0 vs -5.7 in controls; p<0.01).
Why the study?
Does adenosine improve postischemic recovery of function in stunned myocardium in animal models?
Does adenosine improve postischemic recovery of function in stunned myocardium in animal models?
Absolute Event Rate: 7% vs -5.7%
p-value: p=<0.01
Adenosine protects against myocardial stunning and improves postischemic functional recovery via A1 receptor-mediated mechanisms in animal models.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for stunned myocardium; leaves open translation of adenosine-mediated recovery to human trials.
Randhawa et al. (1993) studied Myocardial stunning. Adenosine vs. Controls was evaluated on Postischemic recovery of function (systolic wall thickness) (p=<0.01). Exogenous intracoronary adenosine augmented postischemic recovery of function in dogs, significantly enhancing systolic wall thickness (7.0 vs -5.7 in controls; p<0.01).
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