What does this research mean for the field?

Adenosine enhances the recovery of postischemic myocardial function specifically through the activation of adenosine A1 receptors, rather than A2 receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1992AJP Heart and Circulatory Physiology

Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism

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Why the study?

Does adenosine improve recovery of postischemic myocardial function in isolated rat hearts subjected to ischemia and reperfusion?

Structured PICO

Does adenosine improve recovery of postischemic myocardial function in isolated rat hearts subjected to ischemia and reperfusion?

Population

Isolated rat hearts perfused at constant pressure (85 cmH2O) subjected to 30 min of global no-flow ischemia (37 degrees C) and 45 min of reperfusion

Intervention

Adenosine (100 microM) or the adenosine A1 receptor agonist N6-cyclohexyladenosine (CHA; 0.25 microM)

Comparator

Untreated hearts

Outcome

Recovery of preischemic left ventricular developed pressures (LVDP) after 45 min of reperfusionsurrogate

Adenosine enhances postischemic myocardial function recovery via an A1 receptor mechanism in an isolated rat heart model.

Discussion

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Implication

Supports A1 agonism for postischemic recovery in rat hearts; hypothesis-generating for clinical translation.

Cite This Study

Lasley et al. (1992) studied this question.

synapsesocial.com/papers/6a19902e60e90a7f5fea670c https://doi.org/10.1152/ajpheart.1992.263.5.h1460

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Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism

Structured PICO

Discussion

Implication

Cite This Study

Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider