What does this research mean for the field?

Endogenous adenosine exerts A1 receptor-mediated cardioprotection primarily during myocardial ischemia, whereas its overall modulation of infarct size occurs predominantly during reperfusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1994Cardiovascular Research

A1 Receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia

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Why the study?

Does A1 adenosine receptor antagonism during ischemia or reperfusion affect myocardial infarct size in a rabbit model of ischemia-reperfusion?

Population

Anaesthetised open chest rabbits subjected to 30 min regional ischaemia and 120 min reperfusion (n=66)

Comparison

Selective A1 adenosine receptor antagonist… vs Saline vehicle

Design

Preclinical, Randomised to one of six groups

Follow-up

120 min reperfusion

Authors

ZZZeyi ZhaoYunnan Observatories KNKohei NakanishiNagoya University DMD.Scott McGeeCarnegie Mellon University

Discussion

Member takes

Implication

Supports A1-mediated cardioprotection during ischemia in rabbits; hypothesis-generating for timing-specific adenosine effects in clinical ischemia-reperfusion.

Structured PICO

Does A1 adenosine receptor antagonism during ischemia or reperfusion affect myocardial infarct size in a rabbit model of ischemia-reperfusion?

Population

Anaesthetised open chest rabbits subjected to 30 min regional ischaemia and 120 min reperfusion (n=66)

Intervention

Selective A1 adenosine receptor antagonist KW-3902 (1 or 2 mg/kg) or non-selective antagonist SPT (10 mg/kg) administered during ischemia-reperfusion or reperfusion only

Comparator

Saline vehicle

Outcome

Area of necrosis relative to area at risk (An/Ar) assessed by triphenyltetrazolium chloridesurrogate

Endogenous adenosine exerts A1 receptor-mediated cardioprotection primarily during the ischemic period rather than during reperfusion.

Cite This Study

Zhao et al. (1994) studied this question.

synapsesocial.com/papers/6a1e85508a8a69122355fcaa https://doi.org/10.1093/cvr/28.2.270

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Implication

Supports A1-mediated cardioprotection during ischemia in rabbits; hypothesis-generating for timing-specific adenosine effects in clinical ischemia-reperfusion.

A1 Receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A1 Receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider