Why the study?
Does adenosine pretreatment reduce infarct size in a rabbit model of myocardial ischemia and reperfusion?
Does adenosine pretreatment reduce infarct size in a rabbit model of myocardial ischemia and reperfusion?
Pretreatment with adenosine and endogenous adenosine released during ischemia confer cardioprotection by reducing infarct size independent of hemodynamic effects.
Adenosine pretreatment limits infarct size in rabbits; leaves open translation to human reperfusion injury.
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Toombs et al. (1992) studied this question.
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