Why the study?
Does ischaemic preconditioning improve postischaemic contractile function via adenosine in isolated rat hearts?
Population
Isolated ejecting rat heart preparation (n=6 per group)
Comparison
Ischaemic preconditioning vs 10 min of Langendorff perfusion (control group)
Design
Preclinical
Authors
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Preconditioning improves recovery in rat hearts independently of adenosine; leaves open alternative mechanisms and precludes clinical translation.
Does ischaemic preconditioning improve postischaemic contractile function via adenosine in isolated rat hearts?
Ischaemic preconditioning improves postischaemic functional recovery in isolated rat hearts, but this protective effect does not appear to be mediated by adenosine.
Cave et al. (1993) studied this question.
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